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Our RNA-seq data demonstrated increased expression of key components in the p38/JNK MAPK pathway ( pmk-1, pmk-3, mek-1, sek-1 ) under mrps-5 RNAi, which were reversed when mrps-5 is double-knocked down with C32E8.9

Lee HY, Lee GH, Kim DS, et al

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The bifurcated nature of current litigation (with gastrointestinal claims proceeding federally and vision loss claims advancing through state courts) creates pressure on manufacturers from multiple directions simultaneously, increasing the likelihood that Novo Nordisk and Eli Lilly will eventually pursue comprehensive settlement frameworks addressing both injury types